Abstract :Biofilm formation in Candida albicans is one of the important virulence factors causing infections
refractory to antimicrobial agents. The factors responsible for increased resistance include complex
architecture of biofilms, its matrix, increased efflux pumps and metabolic plasticity. Uses of various
medical devices are associated with C. albicans biofilms. This review focuses on different aspects
of Candida albicans biofilms. These include formation of four temporal stages, several important
factors affecting biofilm formation, their resistance to commonly used antifungal agents including
azoles and polyenes, the mechanism of resistance and alternative approaches inhibiting formation
of biofilms (potential antibiofilm drugs). In conclusion, the detailed review of various aspects of
Candida biofilms provide in depth insight of biology and pathogenesis caused by Candida biofilm.
This detailed knowledge will certainly help in the better management of diseases associated with
biofilm formation.